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Yes, Pyridoxal 5′-phosphate (P5P) can effectively lower elevated prolactin levels, with high-dose vitamin B6 supplementation showing a 68.1% reduction in serum prolactin in clinical studies.
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P5P, the active form of vitamin B6, works to lower prolactin through several mechanisms:
The strongest evidence comes from a 2021 randomized double-blind controlled study that demonstrated:
For comparison, the standard medical treatment for hyperprolactinemia is dopamine agonists:
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