Once a lump has formed and you realize oh sh*t I have gynecomastia (gyno), there are only a couple options you have.
Now, the common approach most individuals have when it comes to gyno reversal with drugs is they tank the living hell out their Estrogen by slamming Letrozole, or they load up on Nolvadex.
First off, Letrozole can’t reverse a fully developed lump, although it can greatly reduce the severity of it, as well as prevent it from getting worse.
In some less severe cases, Letrozole can fully reverse partially developed gyno.
The reason being that Letrozole is an Aromatase Inhibitor (AI), and Nolvadex is a Selective Estrogen Receptor Modulator (SERM).
The mechanism of action behind an AI is that it inhibits the aromatization of Estrogen, thus preventing the hormone that causes gyno from accruing and exacerbating the issue further.
A SERM on the other hand acts as an antagonist and binds to the Estrogen receptor in breast tissue without activating it.
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