Complete Melanotan dosage guide — how to dose MT-I vs MT-II, loading and maintenance phases, reconstitution, how many vials you need, and UV exposure requirements.
Quick summary: Melanotan II doses start low at 0.25mg to assess tolerance, then typically range 0.5–1mg per injection. Melanotan I uses a different (lower mg/kg) dosing approach. Both are subcutaneous injections. Tanning sessions should be used alongside for melanin activation.
Melanotan I (afamelanotide): Dosed at 16–20mg total for a loading implant (clinical dose), or 0.5–1mg/day subcutaneous in research protocols. MT-I is more selective for MC1R — fewer systemic side effects but slower tanning response.
Melanotan II: More potent, faster-acting, lower doses required. Binds multiple melanocortin receptors — responsible for both the stronger tan and the additional sexual side effects (spontaneous erections in men, increased libido).
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