Ipamorelin + CJC

Ipamorelin + CJC-1295 dosage guide for research: synergistic GH stack protocol, 200-300mcg + 100-200mcg per injection, 2-3x daily SubQ, cycle structure, and …

The top GH secretagogue stack — CJC-1295 and Ipamorelin combined for optimal GH release.

The ipamorelin and CJC-1295 (without DAC) combination is the most widely studied and referenced growth hormone secretagogue stack in contemporary peptide research. It pairs two distinct and complementary mechanisms: ipamorelin, a selective GHRP (growth hormone releasing peptide) that agonizes the ghrelin receptor (GHS-R1a) in the pituitary; and CJC-1295 without DAC (also known as Modified GRF 1-29 or Mod GRF 1-29), a GHRH (growth hormone releasing hormone) analog that agonizes the GHRH receptor. These two receptors are distinct, and their simultaneous activation produces a GH pulse that is significantly larger than either peptide can produce alone — often described as synergistic rather than merely additive. This combination closely mimics the dual endogenous signal (GHRH + ghrelin) through which the hypothalamus and pituitary naturally regulate GH release, making it the most physiologically coherent multi-peptide GH stack in the research literature.

To understand why the ipamorelin + CJC-1295 combination is so widely used, it helps to understand the dual-receptor model of GH release:

This complementary mechanism explains why the stack is used as a reference in comparative GH secretagogue research. For broader context on individual peptide comparisons, see the Growth Hormone Peptides Ranked overview.

If you’ve looked into growth hormone peptides, you’ve probably seen this combination everywhere. Ipamorelin and CJC-1295 (no DAC) is the most popular GH secretagogue stack for a reason: it works synergistically to boost growth hormone release while avoiding most of the side effects that plague other peptides in this category.

But there’s a lot of confusion out there. What’s the difference between CJC-1295 with DAC and without? Is Mod GRF 1-29 the same thing? How do you actually dose this stuff? And what results can you realistically expect?

I’ve been researching and writing about peptides for years, and I’ve put everything you need to know about this combination in one place. This guide covers the science, the practical protocols, and the real-world results people are getting.

Ipamorelin + CJC-1295 (no DAC) is a combination of two peptides that work through different pathways to stimulate your body’s natural growth hormone production. Ipamorelin triggers GH release from stored reserves. CJC-1295 promotes both GH production and release. Together, they produce 2-3x more GH than either peptide alone.

This combination is popular because ipamorelin is the “cleanest” GH peptide available. It doesn’t raise cortisol, doesn’t spike prolactin, and doesn’t cause the extreme hunger that other GH peptides like GHRP-6 are known for.

Before getting into how they work together, let’s break down each peptide on its own.

Ipamorelin is a synthetic pentapeptide (five amino acids) developed by Novo Nordisk. It belongs to a class called Growth Hormone Releasing Peptides (GHRPs), which mimic ghrelin and bind to the ghrelin receptor (GHSR-1a) in your hypothalamus and pituitary gland.

What makes ipamorelin stand out is its selectivity. A 1998 study in the European Journal of Endocrinology found that ipamorelin is the first and most selective GHRP ever developed. It releases growth hormone without affecting cortisol or ACTH, even at doses over 200 times higher than needed for GH release.